SLU-PP-332
Dosage Protocol
SLU-PP-332 is a synthetic agonist of estrogen-related receptors α and γ (ERRα/γ), nuclear receptors that govern mitochondrial biogenesis, oxidative phosphorylation, and aerobic metabolism. It activates many of the same transcriptional programs as endurance exercise, increasing mitochondrial density and fatty acid oxidation in skeletal muscle.
What is SLU-PP-332?
SLU-PP-332 was developed at Washington University School of Medicine as a tool compound for studying ERR-mediated transcription. ERRα and ERRγ regulate the expression of hundreds of genes involved in fatty acid oxidation, mitochondrial biogenesis (via PGC-1α), and oxidative fiber type specification in skeletal muscle.
In preclinical models, SLU-PP-332 administration produced significant improvements in endurance capacity, increased slow-twitch oxidative fiber composition in skeletal muscle, and reduced obesity-related metabolic dysfunction. Like AICAR and GW501516, it represents a class of 'exercise mimetics' that activate exercise-specific transcriptional programs without physical activity.
Dosing Schedule
Parameters documented in published preclinical and clinical research.
| Phase | Dose | Frequency | Duration | Notes |
|---|---|---|---|---|
| Conservative | 250–500 mcg | Once daily oral | Weeks 1–2 | Start low. SLU-PP-332 does NOT dissolve in BAC water — requires DMSO vehicle for any injectable use. |
| Working dose | 500 mcg–1 mg | Once daily oral | Weeks 2–8 | Community oral protocols. Preclinical data used 10 mg/kg IP — human oral equivalents are exploratory. |
| Stack | 500 mcg + AICAR 10 mg | Once daily | Per protocol | ERR + AMPK activation for exercise mimetic stack. Do not inject SLU-PP-332 without DMSO solubilisation. |
| Off cycle | — | — | 4 weeks | Zero human trial data — cautious cycling essential. |
Safety & Side Effects
Academic References
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[1]
Brown EL, et al. (2023). Exercise mimetics: harnessing the therapeutic potential of SLU-PP-332 via ERRα/γ agonism. J Med Chem. 66(11):7270–85. PubMed ↗
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[2]
Matsakas A, et al. (2012). ERRγ-dependent signalling in skeletal muscle promotes oxidative metabolism. EMBO Mol Med. 4(9):867–81. PubMed ↗
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[3]
Huss JM, et al. (2015). The nuclear receptor ERRα is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab. 6(1):25–37. PubMed ↗
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[4]
Giguere V. (2008). Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev. 29(6):677–96. PubMed ↗