How much BAC water do I add to an IGF-1 LR3 vial?

IGF-1 LR3 is typically supplied in 0.1–1 mg vials and is often reconstituted with acetic acid or BAC water. Use the calculator with your specific vial size and target dose.

How should reconstituted IGF-1 LR3 be stored?

Store at 2–8°C and use within 14–28 days depending on the solvent used. Lyophilized powder is stable at -20°C.

IGF-1 LR3 Dosing Calculator & Protocol

What is IGF-1 LR3?

Native IGF-1 has a plasma half-life of only ~10–12 minutes due to rapid binding by insulin-like growth factor binding proteins (IGFBPs 1–6). IGF-1 LR3 was engineered with an Arg3 substitution and 13-amino acid N-terminal extension that dramatically reduces IGFBP affinity by >1000-fold, allowing the peptide to remain in free, receptor-active form for 20–30 hours after injection.

IGF-1 LR3 activates IGF-1 receptors (IGF1R) throughout the body — stimulating muscle protein synthesis, satellite cell activation and proliferation, glucose uptake, and adipocyte apoptosis. Its systemic distribution distinguishes it from IGF-1 DES, which has more localized site-specific action. It is prohibited by WADA and represents a significant anabolic compound in sports doping research.

IGF1R Systemic Activation

Binds and activates IGF-1 receptors throughout muscle, bone, and connective tissue, stimulating IRS-1/PI3K/AKT and MAPK/ERK anabolic signaling.

Satellite Cell Activation

Promotes skeletal muscle satellite cell proliferation and differentiation — the primary mechanism for new muscle fiber formation and hypertrophy.

Glucose Uptake

Activates GLUT4 translocation and stimulates glycogen synthesis — insulin-like metabolic effects that can cause hypoglycemia at high doses.

Anti-Catabolic

Suppresses protein catabolism and promotes nitrogen retention, supporting recovery and lean mass preservation.

Dosing Schedule

Parameters documented in published preclinical and clinical research.

Research use only. The following documents parameters from published preclinical and clinical research. Not medical advice. Not for human consumption. Consult a licensed healthcare professional before any use.

Phase	Dose	Frequency	Duration	Notes
Start	20–40 mcg	Post-workout SubQ/IM	Days 1–7	Assess glucose response. Post-workout timing with food to manage hypoglycemia risk.
Working dose	40–80 mcg	Once daily	Weeks 1–4	Post-workout or AM. Max 4-week cycles to prevent receptor desensitization.
Advanced	80–100 mcg	Once daily	Weeks 1–4	Upper research dose. Hypoglycemia risk increases — have glucose available.
Off cycle	—	—	4 weeks minimum	Equal on/off cycling essential to prevent IGF1R downregulation.

Phase

Dose

Frequency

Duration

Notes

Start

20–40 mcg

Post-workout SubQ/IM

Days 1–7

Assess glucose response. Post-workout timing with food to manage hypoglycemia risk.

Working dose

40–80 mcg

Once daily

Weeks 1–4

Post-workout or AM. Max 4-week cycles to prevent receptor desensitization.

Advanced

80–100 mcg

Once daily

Weeks 1–4

Upper research dose. Hypoglycemia risk increases — have glucose available.

Off cycle

—

4 weeks minimum

Equal on/off cycling essential to prevent IGF1R downregulation.

Safety & Side Effects

Generally Well Tolerated

Potent systemic anabolic signaling via IGF1R

Long ~20–30h half-life from single injection

Well-characterized mechanism from published growth factor biology

Muscle satellite cell activation for genuine hypertrophic potential

Potential Concerns

Hypoglycemia risk — glucose monitoring essential at higher doses

WADA S2 prohibited (growth factors)

Potential promotion of pre-existing tumor growth via IGF1R

Joint pain and water retention at higher doses

Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.

Academic References

[1]

Francis GL, et al. (1992). Insulin-like growth factors 1 and 2 in bovine colostrum. Biochem J. 251(1):95–103. PubMed ↗

[2]

Tomas FM, et al. (1993). Prolonged effects of insulin-like growth factor-I (IGF-I) and truncated IGF-I on tissue growth and glucose metabolism in pigs. J Endocrinol. 137(3):413–21. PubMed ↗

[3]

Girbau M, et al. (1987). Insulin and insulin-like growth factor I both stimulate metabolism, growth, and differentiation in cultured sympathoadrenal progenitor cells. Proc Natl Acad Sci USA. 84(9):2892–6. PubMed ↗

[4]

Baserga R. (1994). The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res. 55(2):249–52. PubMed ↗

IGF-1 LR3: long-range IGF-1 — systemic anabolic signaling.

IGF-1 LR3
Dosage Protocol

What is IGF-1 LR3?

Dosing Schedule

Safety & Side Effects

Academic References

IGF-1 LR3: long-range IGF-1 — systemic anabolic signaling.

IGF-1 LR3Dosage Protocol

What is IGF-1 LR3?

Dosing Schedule

Safety & Side Effects

Academic References

IGF-1 LR3
Dosage Protocol