How much BAC water do I add to a sermorelin vial?

Sermorelin is commonly supplied in 3–9 mg vials. Use 1–3 mL of BAC water depending on your target concentration. The calculator shows exact draw volumes for any input.

What is the concentration from 3 mL BAC water in a 9 mg vial?

3 mg/mL (3000 mcg/mL). A 300 mcg dose equals 0.1 mL, which is 10 units on a U-100 insulin syringe.

How should reconstituted sermorelin be stored?

Store at 2–8°C and use within 28 days. Protect from light. Lyophilized powder is stable at -20°C long-term.

Sermorelin Dosing Calculator & Protocol

What is Sermorelin?

Sermorelin is the shortest synthetic peptide retaining full GHRH biological activity — comprising only the first 29 amino acids of the 44-amino acid native GHRH molecule. It binds GHRH receptors on pituitary somatotrophs and stimulates endogenous GH synthesis and pulsatile secretion. Unlike direct GH administration, sermorelin preserves natural feedback loops.

Its former FDA approval and extensive clinical dataset make it one of the better-documented secretagogues. It is administered at bedtime to amplify the natural nocturnal GH surge during slow-wave sleep. Sermorelin is frequently combined with Ipamorelin for GHRH + GHRP synergy, producing significantly greater GH output than either compound alone.

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GHRH Receptor Binding

Activates GHRH receptors (GHRHR) on anterior pituitary somatotrophs via Gs-protein coupling and adenylyl cyclase, increasing intracellular cAMP and triggering GH release.

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Nocturnal GH Amplification

Bedtime administration synergizes with natural slow-wave sleep GH pulse, producing the body's largest physiological GH surge of the day.

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Feedback Loop Preservation

Unlike exogenous GH, sermorelin preserves the GH/IGF-1 negative feedback axis, preventing the suppression of endogenous GH production.

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IGF-1 Upregulation

Downstream GH signaling drives hepatic IGF-1 production, supporting lean mass, recovery, metabolic rate, and skin integrity.

Dosing Schedule

Parameters documented in published preclinical and clinical research.

⚠️ Research use only. The following documents parameters from published preclinical and clinical research. Not medical advice. Not for human consumption. Consult a licensed healthcare professional before any use.

Phase	Dose	Frequency	Duration	Notes
Start	100 mcg	Once nightly	Weeks 1–2	Fasted SubQ. Monitor injection site reactions and sleep quality.
Working dose	200–300 mcg	Once nightly	Weeks 3–12	Standard protocol. Take 2h after last meal, 30–60 min before bed.
Advanced	500 mcg	Once nightly	If needed	For non-responders with low IGF-1 after 6 weeks at standard dose.
Off cycle	—	—	1–2 months	5-days-on / 2-days-off cycling is also commonly used.

Phase

Dose

Frequency

Duration

Notes

Start

100 mcg

Once nightly

Weeks 1–2

Fasted SubQ. Monitor injection site reactions and sleep quality.

Working dose

200–300 mcg

Once nightly

Weeks 3–12

Standard protocol. Take 2h after last meal, 30–60 min before bed.

Advanced

500 mcg

Once nightly

If needed

For non-responders with low IGF-1 after 6 weeks at standard dose.

Off cycle

—

1–2 months

5-days-on / 2-days-off cycling is also commonly used.

Safety & Side Effects

✓ Generally Well Tolerated

Former FDA approval — most clinically documented GHRH analog

Preserves natural GH feedback loops

Pulsatile release pattern — low desensitization risk

Well tolerated; injection site reactions the primary complaint

⚠ Potential Concerns

Transient facial flushing at higher doses

Anti-GRF antibodies may form (generally clinically insignificant)

GH response blunted by food / elevated glucose

Underactive thyroid may reduce efficacy

⚠️

Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.

Academic References

[1]

Walker RF. (2006). Sermorelin: a better approach to management of adult-onset growth hormone insufficiency. Clin Interv Aging. 1(4):307–8. PubMed ↗

[2]

Prakash A, Goa KL. (1999). Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic GH deficiency. BioDrugs. 12(2):139–57. PubMed ↗

[3]

Vittone J, et al. (1997). Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 46(1):89–96. PubMed ↗

[4]

Corpas E, et al. (1993). Continuous subcutaneous infusions of growth hormone (GH)-releasing hormone augment pulsatile, entropic, and daily rhythmic GH secretion in old men. J Clin Endocrinol Metab. 76(1):133–7. PubMed ↗

Sermorelin: the original GHRH — FDA-pedigreed.

Sermorelin
Dosage Protocol

What is Sermorelin?

Dosing Schedule

Safety & Side Effects

Academic References

Sermorelin: the original GHRH — FDA-pedigreed.

SermorelinDosage Protocol

What is Sermorelin?

Dosing Schedule

Safety & Side Effects

Academic References

Sermorelin
Dosage Protocol