GHK-Cu
Dosage Protocol
GHK-Cu (copper peptide) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. It is one of the most researched peptides in skin regeneration and longevity science, with demonstrated activity in collagen synthesis, wound healing, and gene expression modulation affecting 31% of all human genes.
What is GHK-Cu?
GHK-Cu (Gly-His-Lys-Cu2+) is a tripeptide that occurs naturally in the body, with plasma concentrations declining significantly with age. Research has demonstrated its ability to stimulate collagen, fibronectin, and decorin synthesis; activate wound-healing pathways; and modulate a broad array of gene expression — including genes related to inflammation, nervous system function, and cancer suppression.
Its copper-chelating ability may also contribute to antioxidant activity, while its role as a growth signal appears to operate via fibroblast activation. The compound is studied both for systemic longevity mechanisms (subcutaneous) and local skin regeneration (topical application or intradermal injection).
Dosing Schedule
Parameters documented in published preclinical and clinical research.
| Phase | Dose | Frequency | Duration | Notes |
|---|---|---|---|---|
| Conservative | 0.5–1 mg | Once daily | 8 weeks | Starting dose for systemic research. GHK-Cu requires extended use — effects build over 8–12 weeks. |
| Standard typical | 1–2 mg | Once daily | 8–12 weeks | Most research falls in this range. Minimum 8 weeks for meaningful collagen outcomes. |
| Topical / Intradermal | Variable | Daily as needed | Ongoing | For skin-specific research. Concentration depends on formulation. |
| Off cycle | — | — | 4 weeks | Rest between systemic cycles. |