Once or twice daily
Frequency
Overview
What is BPC-157?
BPC-157 is a synthetic pentadecapeptide derived from a naturally occurring protein found in human gastric juice. It was first isolated in research on the stomach's remarkable ability to resist acid damage. Its cytoprotective properties have made it one of the most studied peptides in preclinical tissue-repair research.
Unlike anabolic peptides that work hormonally, BPC-157 operates through local signalling pathways — upregulating growth factor receptors, stimulating angiogenesis, and activating the FAK-paxillin pathway for fibroblast migration and collagen deposition at injury sites.
🩸Angiogenesis
Stimulates VEGFR2 and eNOS upregulation, promoting new blood vessel formation at injury sites for improved oxygen and nutrient delivery.
🧬FAK-Paxillin Pathway
Activates focal adhesion kinase signalling, driving fibroblast migration and collagen type I deposition — the primary mechanism for connective tissue repair.
🛡️Gut Cytoprotection
Protects the mucosal barrier, reduces inflammation, and supports healing of ulcers and NSAID-induced gastrointestinal lesions.
💊NO-System Modulation
Interacts with nitric oxide signalling to reduce local inflammation while maintaining vascular tone.
Source at White Market Peptides — PEPPERCALC10 10% off
Dosing Protocol
Dosing Schedule
Parameters documented in published preclinical and clinical research.
⚠️ Research use only. The following documents parameters from published preclinical and clinical research. Not medical advice. Not for human consumption. Consult a licensed healthcare professional before any use.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Start | 250 mcg | Once daily | Days 1–5 | Tolerance assessment. Published protocols have used sites proximal to target tissue or abdomen depending on study objective. |
| Working dose standard | 500 mcg | Once or twice daily | Day 6 → end of cycle | Most research falls in this range. Split dosing (250 mcg AM + 250 mcg PM) may improve tissue saturation. |
| High dose | 600–800 mcg | Once or twice daily | Weeks 3–4 only | Used in some acute injury protocols. Not recommended as a starting point. |
| Off cycle | — | — | 2 weeks | Rest period before restarting. |
Common Questions
Frequently Asked Questions
How much BAC water should I add to a BPC-157 vial?
The most common reconstitution volumes are 1–2 mL for a 5 mg vial and 2–3 mL for a 10 mg vial, depending on your target dose. Use the calculator above to find the volume that gives the most convenient draw amount for your syringe.
What concentration does 2 mL of BAC water give with a 5 mg BPC-157 vial?
2 mL into a 5 mg vial gives a concentration of 2.5 mg/mL (2500 mcg/mL). A 250 mcg dose requires drawing 0.1 mL, which equals 10 units on a U-100 insulin syringe.
How long does reconstituted BPC-157 stay stable?
Reconstituted BPC-157 is generally considered stable for up to 28–30 days when stored at 2–8°C and protected from light. Lyophilized powder stored at -20°C is stable for much longer.
What syringe should I use for BPC-157 research?
U-100 insulin syringes (1 mL, 100 units) are standard for research applications due to their precision. PepperCalc's results are expressed in U-100 units by default.
Ready to source your compounds?
White Market Peptides
Third-party tested, 99%+ purity, shipped from the USA. Every batch published to our COA library.
Use code PEPPERCALC10 for 10% off · Free shipping over $200
Verified reviews on Trustpilot