How much BAC water do I add to a DSIP vial?

DSIP is typically supplied in 5–10 mg vials. Use 1–2 mL of BAC water. The calculator shows exact draw amounts for your target dose.

How should reconstituted DSIP be stored?

Store at 2–8°C and use within 28 days. Lyophilized powder is stable at -20°C.

DSIP Dosing Calculator & Protocol

What is DSIP?

DSIP was discovered in 1977 by Monnier and colleagues who observed that dialysate from the thalamic region of sleeping rabbits could induce delta sleep in awake animals. The peptide sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu was subsequently synthesized and confirmed to retain sleep-promoting activity. It is found in the brain, pituitary, and peripheral tissues.

Beyond sleep induction, DSIP appears to regulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing chronic cortisol elevation and normalizing disturbed circadian hormone rhythms. It has been studied for pain management, alcohol withdrawal, and stress-related disorders. Its broad neuroendocrine regulatory effects make it of interest for recovery optimization in research contexts.

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Delta Sleep Induction

Acts on central sleep-regulating circuits to promote slow-wave (delta) sleep — the most restorative sleep stage critical for GH release and tissue repair.

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HPA Axis Normalization

Modulates hypothalamic-pituitary-adrenal function, reducing chronically elevated cortisol and normalizing disturbed circadian ACTH rhythms.

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Neuroendocrine Regulation

Influences release of multiple pituitary hormones including GH, LH, and TSH, with normalizing effects on dysregulated hormone patterns.

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Antistress Properties

Demonstrated antistress and potentially analgesic effects in animal models, reducing stress-induced corticosterone elevation.

Dosing Schedule

Parameters documented in published preclinical and clinical research.

⚠️ Research use only. The following documents parameters from published preclinical and clinical research. Not medical advice. Not for human consumption. Consult a licensed healthcare professional before any use.

Phase	Dose	Frequency	Duration	Notes
Research	100–200 mcg	Evening SubQ	As needed	Evening Subcutaneous administration 30–60 min before intended sleep.
Working dose	200–500 mcg	Evening SubQ	Short courses	Higher doses may be needed for pronounced sleep disruption research.
IV protocol	25 mcg/kg	IV slow infusion	Clinical studies	IV delivery used in original clinical sleep research protocols.
Cycling	5 days on / 2 off	Evening	3–4 weeks	Cycle to assess sustained effects on sleep architecture.

Phase

Dose

Frequency

Duration

Notes

Research

100–200 mcg

Evening SubQ

As needed

Evening Subcutaneous administration 30–60 min before intended sleep.

Working dose

200–500 mcg

Evening SubQ

Short courses

Higher doses may be needed for pronounced sleep disruption research.

IV protocol

25 mcg/kg

IV slow infusion

Clinical studies

IV delivery used in original clinical sleep research protocols.

Cycling

5 days on / 2 off

Evening

3–4 weeks

Cycle to assess sustained effects on sleep architecture.

Safety & Side Effects

✓ Generally Well Tolerated

Endogenous peptide — naturally present in human brain and periphery

Promotes restorative slow-wave sleep without benzodiazepine mechanism

Normalizes HPA axis function rather than suppressing it

Generally well tolerated in published studies

⚠ Potential Concerns

Limited modern clinical trial data — most research from 1970s–90s

Variable individual response — some report minimal sleep effect

Short plasma half-life — IV preferred in formal studies

Long-term effects on sleep regulation not well established

⚠️

Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.

Academic References

[1]

Monnier M, et al. (1977). The delta sleep-inducing peptide (DSIP). Experientia. 33(4):548–52. PubMed ↗

[2]

Schneider-Helmert D. (1984). DSIP in insomnia. Eur Neurol. 23(5):358–63. PubMed ↗

[3]

Khvatova EM, et al. (2003). Delta sleep inducing peptide (DSIP): effect on respiration activity in mitochondria. Peptides. 24(2):307–11. PubMed ↗

[4]

Graf MV, Kastin AJ. (1986). Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 10(3):303–45. PubMed ↗

DSIP: delta sleep induction — sleep deeper, recover faster.

DSIP
Dosage Protocol

What is DSIP?

Dosing Schedule

Safety & Side Effects

Academic References

DSIP: delta sleep induction — sleep deeper, recover faster.

DSIPDosage Protocol

What is DSIP?

Dosing Schedule

Safety & Side Effects

Academic References

DSIP
Dosage Protocol