BPC-157 + TB-500
Daily Dose
Daily + 2× weekly
Frequency
Overview
What is Wolverine Stack?
BPC-157 and TB-500 complement each other through distinct, non-overlapping mechanisms. BPC-157 activates local signalling — FAK-paxillin for fibroblast migration, VEGFR2 for local angiogenesis, and direct gut cytoprotection. TB-500 acts systemically through actin sequestration, promoting cell migration and blood vessel formation throughout the body.
The rationale for combining them: BPC-157 provides targeted, localised activity at the injury site (especially effective when injected nearby), while TB-500's systemic reach can improve healing across multiple tissues simultaneously. Animal models suggest the combination may produce additive effects on recovery speed and tissue quality vs either compound alone.
🎯BPC-157: Local Action
FAK-paxillin pathway activation drives fibroblast migration and collagen deposition at the injury site.
🌐TB-500: Systemic Action
Actin sequestration promotes cell migration and new vessel formation throughout the body.
🩸Combined Angiogenesis
Both compounds independently stimulate blood vessel formation — potentially additive vascular effects.
⚡Complementary Timing
BPC-157 daily for continuous local signalling; TB-500 twice weekly for systemic loading.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for Wolverine Stack
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| BPC-157 | 250–500 mcg | Once or twice daily | 4–6 weeks | Inject near injury site or abdomen. Daily administration sustains local signalling. |
| TB-500 — Loading weeks 1–4 | 5–10 mg | Twice weekly | 4 weeks | Higher loading dose to saturate tissue and initiate systemic healing cascade. |
| TB-500 — Maintenance | 2.5–5 mg | Once or twice weekly | Weeks 5–6+ | Reduced dose to sustain repair effects. |
| Off cycle | — | — | 4 weeks | Full rest from both compounds before next research cycle. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🎯
BPC-157: Near Injury
Inject BPC-157 within 2–5 cm of the injury site for targeted local action.
🌐
TB-500: Abdomen / Thigh
TB-500 can be injected anywhere — systemic action means site is less critical.
📅
Scheduling
BPC-157 daily (or split AM/PM). TB-500 Monday + Thursday is a common twice-weekly schedule.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Additive mechanisms without overlapping adverse effects
Well-researched individual compounds
No hormonal disruption
Flexible dosing schedule for each component
⚠ Potential Concerns
Both compounds WADA-prohibited (S2)
More complex protocol than single-compound research
Increased cost vs individual compounds
Limited stack-specific human trial data
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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