Overview
What is Tesamorelin?
Unlike direct growth hormone peptides (GHRPs) or exogenous GH, tesamorelin works upstream at the GHRH receptor on pituitary somatotroph cells, stimulating pulsatile endogenous GH secretion. This preserves physiological feedback mechanisms, reducing the risk of GH-related adverse effects associated with supraphysiological GH exposure.
Tesamorelin (Egrifta) has FDA approval for HIV-associated lipodystrophy — visceral fat accumulation in HIV-positive patients on antiretroviral therapy. Research interest extends to metabolic health, body composition, cognitive function (particularly in early Alzheimer's research), and age-related GH decline.
🧬GHRH Receptor Agonism
Binds GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH release with preserved feedback inhibition.
⚡IGF-1 Upregulation
Increased GH leads to elevated IGF-1 — mediating anabolic and lipolytic downstream effects.
🔥Visceral Fat Reduction
GH and IGF-1 promote lipolysis in visceral adipose tissue — the primary mechanism studied for body composition effects.
🧠Neuroprotective Research
Emerging research on GH axis restoration in cognitive decline and Alzheimer's disease models.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for Tesamorelin
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Standard typical | 1 mg | Once daily (evening) | 3–6 months | Most common research protocol. Evening dosing aligns with natural GH pulse timing. |
| Higher dose | 2 mg | Once daily | 3–6 months | Used in some body composition research protocols. |
| Off cycle | — | — | 1–2 months | Rest period between extended research cycles. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🫃
Abdomen
SubQ injection into lower abdominal fat. Standard for tesamorelin research.
🕙
Evening Dosing
Evening administration aligns with the body's natural GH secretion pattern for research consistency.
🔄
Site Rotation
Rotate within the abdominal region daily to prevent lipohypertrophy.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Physiological pulsatile GH release (not supraphysiological)
FDA-approved pharmaceutical precedent
Preserved feedback inhibition vs direct GH
Well-characterised in clinical trial data
⚠ Potential Concerns
Water retention and joint discomfort at higher doses
Potential insulin resistance with extended use
Oedema in some subjects
Contraindicated in active malignancy — always screen carefully
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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