0.25–2.4 mg/week
Daily Dose
Overview
What is Semaglutide?
GLP-1 (glucagon-like peptide-1) is an incretin hormone released from intestinal L-cells in response to food intake. Semaglutide mimics this hormone with a much longer half-life, achieved by structural modification and albumin binding. It activates GLP-1 receptors in the pancreas, gut, liver, and brain — reducing appetite, slowing gastric emptying, and improving insulin sensitivity.
Research interest in semaglutide focuses on metabolic regulation, weight management mechanisms, and emerging neuroprotective and cardiovascular applications. Its long half-life allows once-weekly administration, and dose titration over several months is standard in research protocols to minimise GI side effects.
🧠Appetite Suppression
Acts on hypothalamic GLP-1 receptors to reduce hunger signals and caloric intake.
🍽️Gastric Emptying
Slows gastric emptying, extending satiety after meals and blunting postprandial glucose spikes.
⚡Insulin Secretion
Stimulates glucose-dependent insulin release from pancreatic beta cells while suppressing glucagon.
❤️Cardiovascular
Emerging research on cardioprotective and neuroprotective mechanisms of GLP-1 signalling.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for Semaglutide
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Start weeks 1–4 | 0.25 mg | Once weekly | 4 weeks | Tolerance phase. GI side effects most common here — start low. |
| Increase | 0.5 mg | Once weekly | Weeks 5–8 | If 0.25 mg tolerated well. Standard maintenance dose for many research protocols. |
| Increase | 1.0 mg | Once weekly | Weeks 9–16 | Advance if further metabolic effects desired. |
| High dose | 1.7–2.4 mg | Once weekly | Week 17+ | Highest doses studied for weight management research. Advance cautiously. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🫃
Abdomen
Preferred injection site. Inject into subcutaneous fat of lower abdomen, 2 inches from navel.
🦵
Thigh
Outer thigh subcutaneous fat. Easy self-injection site with consistent absorption.
💪
Upper Arm
Outer upper arm, subcutaneous. Typically requires assistance for self-injection.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Long-acting, once-weekly dosing simplifies research protocols
Well-characterised mechanism of action
No androgenic or hormonal disruption
Extensive clinical trial safety data available
⚠ Potential Concerns
Nausea, vomiting, diarrhoea — especially on dose escalation
Injection site reactions
Potential thyroid C-cell effects in animal models
Not suitable for subjects with personal/family history of MTC
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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