Overview
What is MOTS-c?
MOTS-c is encoded by the 12S ribosomal RNA gene within the mitochondrial genome — an unusual origin for a bioactive peptide. Research has demonstrated its ability to activate AMPK (AMP-activated protein kinase), the key cellular energy sensor, which in turn promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. These are the same pathways activated by aerobic exercise.
Animal model research has shown MOTS-c improves insulin sensitivity, reduces age-related decline in exercise capacity, and activates longevity-associated gene expression pathways including AMPK/SIRT1 signalling. Its systemic reach — acting in muscle, liver, and adipose tissue — makes it a compelling research target for both metabolic disease and longevity science.
⚡AMPK Activation
Activates AMP-activated protein kinase — the master metabolic switch controlling glucose uptake and fat oxidation.
🏃Exercise Mimicry
Produces metabolic adaptations similar to aerobic exercise without mechanical stimulus in animal models.
🔋Mitochondrial Biogenesis
May promote mitochondrial number and efficiency through AMPK/PGC-1α signalling.
⏳Longevity Pathways
Activates SIRT1 and related pathways associated with extended healthspan in research models.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for MOTS-c
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Conservative | 5 mg | Daily (5 on / 2 off) | 4 weeks | Starting dose for MOTS-c research. |
| Standard typical | 10 mg | Daily (5 on / 2 off) | 4–8 weeks | Most common research dose range. |
| Off days | — | — | Weekends | Two-day break per week is the standard cycling approach. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🫃
Abdomen
Subcutaneous injection into lower abdominal fat.
🦵
Thigh
Outer thigh subcutaneous.
🏥
IV (Research Only)
Intravenous administration used in some animal model studies. SubQ is standard for most research.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Endogenous peptide — naturally produced in the body
No androgenic or hormonal effects
Novel but promising safety signals in animal research
No reported significant adverse effects in short-term studies
⚠ Potential Concerns
Limited human clinical data
Optimal dosing protocols still being established
IV administration adds complexity
Sourcing and purity verification critical given research-stage status
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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