Overview
What is GHK-Cu?
GHK-Cu (Gly-His-Lys-Cu2+) is a tripeptide that occurs naturally in the body, with plasma concentrations declining significantly with age. Research has demonstrated its ability to stimulate collagen, fibronectin, and decorin synthesis; activate wound-healing pathways; and modulate a broad array of gene expression — including genes related to inflammation, nervous system function, and cancer suppression.
Its copper-chelating ability may also contribute to antioxidant activity, while its role as a growth signal appears to operate via fibroblast activation. The compound is studied both for systemic longevity mechanisms (subcutaneous) and local skin regeneration (topical application or intradermal injection).
✨Collagen Synthesis
Stimulates collagen I, III, and fibronectin production in fibroblasts — key mechanism for skin repair and wound healing.
🧬Gene Modulation
Shown to modulate over 31% of human genes in research; affects inflammation, apoptosis, and tissue remodelling pathways.
🛡️Antioxidant
Copper complex contributes to antioxidant defence; may reduce oxidative stress in aged tissues.
⏳Longevity Signalling
Declining GHK-Cu with age correlates with tissue degeneration; supplementation studied for longevity-related mechanisms.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for GHK-Cu
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Conservative | 0.5–1 mg | Once daily | 4 weeks | Starting dose for systemic research. |
| Standard typical | 1–2 mg | Once daily | 4–8 weeks | Most research falls in this range. |
| Topical / Intradermal | Variable | Daily as needed | Ongoing | For skin-specific research. Concentration depends on formulation. |
| Off cycle | — | — | 2–4 weeks | Rest between systemic cycles. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🫃
Abdomen
Standard subcutaneous injection for systemic GHK-Cu research protocols.
🦵
Thigh
Outer thigh subcutaneous fat. Rotate sites daily.
💉
Intradermal
For localised skin research — requires fine-gauge needle and appropriate training.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Naturally occurring in human body
Excellent topical safety profile
No androgenic effects
Broad research base with favourable safety signals
⚠ Potential Concerns
Systemic subcutaneous use has less data than topical
Potential skin discolouration at high intradermal doses
Copper accumulation theoretical concern with extended use
Injection site reactions possible
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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