Once or twice daily
Frequency
Overview
What is BPC-157?
BPC-157 is a synthetic pentadecapeptide derived from a naturally occurring protein found in human gastric juice. It was first isolated in research on the stomach's remarkable ability to resist acid damage. Its cytoprotective properties have made it one of the most studied peptides in preclinical tissue-repair research.
Unlike anabolic peptides that work hormonally, BPC-157 operates through local signalling pathways — upregulating growth factor receptors, stimulating angiogenesis, and activating the FAK-paxillin pathway for fibroblast migration and collagen deposition at injury sites.
🩸Angiogenesis
Stimulates VEGFR2 and eNOS upregulation, promoting new blood vessel formation at injury sites for improved oxygen and nutrient delivery.
🧬FAK-Paxillin Pathway
Activates focal adhesion kinase signalling, driving fibroblast migration and collagen type I deposition — the primary mechanism for connective tissue repair.
🛡️Gut Cytoprotection
Protects the mucosal barrier, reduces inflammation, and supports healing of ulcers and NSAID-induced gastrointestinal lesions.
💊NO-System Modulation
Interacts with nitric oxide signalling to reduce local inflammation while maintaining vascular tone.
Reconstitution
Reconstitution Calculator
Enter your vial size and BAC water volume to calculate your exact concentration, syringe units, and number of doses per vial.
Interactive Calculator
Dose Planner for BPC-157
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Step-by-step
How to reconstitute
1
Gather supplies
Lyophilised peptide vial, bacteriostatic water, a drawing syringe (1–3 mL), U-100 insulin syringes for dosing, and alcohol swabs. Work on a clean surface.
2
Swab and dry
Wipe stoppers on both vials with alcohol swabs. Wait 10–15 seconds for full evaporation before piercing. Never blow or touch after swabbing.
3
Add BAC water slowly
Draw BAC water into your syringe, insert into peptide vial, and inject slowly down the inside glass wall — never directly onto the powder cake.
4
Swirl gently — do not shake
Roll the vial between your palms until powder fully dissolves. Solution should be clear and colourless. Shaking degrades the peptide.
💡 If still cloudy after 2 minutes, gently swirl again and wait. Discard if permanent cloudiness or particulates appear.
5
Label and refrigerate
Label with compound name, concentration, and reconstitution date. Store at 2–8 °C. Most reconstituted peptides are stable for 4–6 weeks refrigerated.
Dosing Protocol
Dosing Schedule
Research-derived dosing ranges. Always begin conservatively to assess tolerance.
| Phase | Dose | Frequency | Duration | Notes |
|---|
| Start | 250 mcg | Once daily | Days 1–5 | Tolerance assessment. Inject near injured tissue or abdomen for gut goals. |
| Working dose standard | 500 mcg | Once or twice daily | Day 6 → end of cycle | Most research falls in this range. Split dosing (250 mcg AM + 250 mcg PM) may improve tissue saturation. |
| High dose | 600–800 mcg | Once or twice daily | Weeks 3–4 only | Used in some acute injury protocols. Not recommended as a starting point. |
| Off cycle | — | — | 2 weeks | Rest period before restarting. |
🌶️
Use the PepperCalc calculatorEnter your exact vial size and BAC water above to get your precise syringe units for each dose. No guesswork.
Administration
Injection Sites
🎯
Near Injury
SubQ injection 2–5 cm from the injury site. Standard for tendon, ligament, and muscle repair research.
🫃
Abdomen
Preferred for gut applications (IBD, ulcers). Inject into subcutaneous fat of the lower abdomen.
🔄
Site Rotation
If dosing twice daily, alternate sides to prevent localised irritation.
Safety Profile
Safety & Side Effects
✓ Generally Well Tolerated
Excellent safety profile in animal models
No reported hormonal disruption
Well tolerated at standard doses
No known significant drug interactions in research
⚠ Potential Concerns
Nausea or dizziness at high doses (rare)
Injection site redness or mild swelling
Long-term human safety data limited
Prohibited in competitive sports (WADA S2)
⚠️
Research use onlyThis page is an educational reference. None of this constitutes medical advice. Consult a qualified professional before any use. All compounds are for research purposes only.
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